产品货号：
Z36044
中文名称：
PAG1 Purified抗体
英文名称：
Anti-PAG1 Purified Antibody (Clone#PAG-C1)
产品规格：
0.1mg(C100)
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-PAG1 Purified Antibody (Clone#PAG-C1) |
| 指标别名 | CBP;Csk binding protein;PAG;PAG1 |
| 克隆性 | Monoclonal |
| 检验物种 | rat,cow,human,mouse |
| 应用范围 | IP,WB,IHC |
| 基因名称 | PAG1 |
| 克隆号 | PAG-C1 |
| 抗体来源 | Mouse |
| 抗体类型 | IgG2b |
| 免疫原 | C-terminal peptide (last 15 amino acids) of human Csk binding protein coupled to KLH.The antibody PAG-C1 recognizes an epitope located in the intracellular C-terminal domain of Csk-binding protein (Cbp/PAG),a 46kDa ubiquitously expressed transmembrane adaptor protein present in membrane rafts (glycosphingolipid-enriched microdomains),which however migrates on SDS PAGE gels anomalously as an 80kDa molecule. |
| 计算分子量 | 47kDa |
| 成分 | Phosphate buffered saline (PBS),pH7.4,15mM sodium azide |
| 纯化方式 | Purified by protein-A affinity chromatography. |
| 浓度 | 1mg/mL |
| 产品形态 | 溶液 |
| 保存条件 | Store at 2～8℃.Do not freeze. |
| 背景资料 | PAG (phosphoprotein associated with GEMs),also known as Cbp (Csk-binding protein),is a ubiquitously expressed 46kDa transmembrane adaptor protein present in membrane rafts (glycosphingolipid-enriched microdomains),which however migrates on SDS PAGE gels anomalously as an 80kDa molecule.Following tyrosine phosphorylation by Src family kinases,PAG binds and thereby activates the protein tyrosine kinase Csk,the major negative regulator of the Src family kinases.Signaling via the B-cell receptor in B cells or high affinity IgE receptor (FcepsilonRI) in mast cells leads to PAG increased tyrosine phosphorylation and Csk binding,while T cell receptor signaling causes PAG dephosphorylation,loss of Csk binding and increased activation of the protein tyrosine kinase Lck. |
| Uniprot ID | Q3U1F9 |
| 基因名全称 | Phosphoprotein membrane anchor with glycosphingoli |
| 蛋白名全称 | Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 |
| 推荐稀释比 | Immunohistochemistry (paraffin sections):Positive tissue:appendix (germinal center of lymphatic follicle),heat-mediated antigen retrieval in citrate buffer pH6.1. Immunoprecipitation:Positive control:RAJI human Burkitt lymphoma cell line. |
相关搜索：PAG1 Purified抗体，PAG1 Purified单抗，Anti-PAG1 Purified Antibody (Clone#PAG-C1)